Ch. Destri Wiwis Wijayanti, I Ketut Sudiana, Jusak Nugraha


Aphthous ulcer is the most common oral mucosal disease occurring in up to 25% of the world's human population. In general, therapy is more directed to pain control and hope of faster healing. Increased use of the drug with the original content on the grounds more free toxic effects, easy to obtain and affordable prices cause the use of plants as ingredients of medicine to be an alternative choice. Jatropha multifida known as betadin plant is a plant with bioactive ingredients flavonoids, diterpenoid, tannins and saponins have been widely used as medicinal plants.Research on aphthous ulcer in mouth mucosal of Rat norvegicus was made by using heated burnisher and using 54 Rat norvegicus rats divided into five groups were normal group, K0 (CMC-Na3%), P1 (2.5% JM); P2 (5% JM) and P3 (JM 10%). Giving a topical extract of J.multifida done 2 times a day then sacrificed on day 3 and day 5. VEGF expression in aphthous ulcer in the mouth tissue by immunohistochemical staining. The result of statistical analysis on VEGF expression showed significant difference (p <0,05) at concentration of J.multifida 10% extract where the wound healing process in mouse mucosa was better.


Aphthous ulcer, Vascular endothelial growth factor, Jatropha multifida

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Anabel Diaz, Otilia Pereira-Lopez, Elisabete Barbosa, Pedro Mesquita, Filipe Coimbra, 2015. Behaviour of The Recurrent Aphthous Stomatitis as a Dental Urgency at Vedado’s university Policlinic. Faculty of Detal Medicine, University of Porto – Original Research. Portugal.

Aceng Ruyani, Agus Sundaryono, Hery Haryanto, 2010. Pengembangan Tumbuhan Betadine (Jatropha multifida Linn.) Untuk Meningkatkan Jumlah Trombosit pada Penderita Penyakit Demam Berdarah Dengue. FKIP Universitas Bengkulu. Indonesia.

Al Samadi, A. Drozd, A Salem, J. Hietanen, R. Hayrinen-Imonen, Y.T. Konttinen, 2015. Epithelial Cell Apoptosis in Recurrent Aphthous Ulcer. Journal of Dental Research vol. 94 (7) 928-935. Institiute of Clinical Medicine Biomedicum, Helsinki. Finland.

Anthony L. Mescher, 2013. Basic Histology Text and Atlas. Thirteenth edition. McGraw Hill e-book. Indiana.

Beatrize C. K. Hirota, Cristina M.S. Miyazaki, Camila A. Mercali, Maria C. Verdan, Milena Kalegari, Carlos Gemin, Ana L.L. Lordello, Marilis D. Miguel, Obdulio G. Miguel, 2012. C-Glycosyl Flavones and Comparative Study of The Antioxidant, Hemolytic, and Toxic Potential of Jatropha multifida Leaves and Bark. International journal of Phytomedicine 4. 01-05. Brazil.

Bodhu Sashi Kanth, Avula Satya Kumar, Digambar Balaji Shinde, Kothapali Hari Babu, Tuniki Venugopal Raju, Chityal Ganesh Kumar, Pombala Sujitha, Biswanath Das, 2011. New Bioactive Macrocyclic Diterpenoid from Jatropha multifida. Journal Elsevier Bioorganic

and Medicinal Chemistry Letters 21 (2011) 6808-6810. India.

G. Leoni, P.A. Neumann, R. Sumagin, T.L. Dening, A. Nusrat, 2015. Wound Repair : Role of Immune – EpithelialInteraction. Mucosal Immunology. Nature Publishing Group. Review.

Hannu Larjava, 2012. Oral Wound Healing : Cell Biology and Clinical Management. Ulcer Healing Book. Vancouver, Canada.

Jazwa Agniezka, Paulina Kucharzewska, Justyna Leja, Anna Zagorska,

Aleksandra Sierpniowska, Jacek Stepniewski, Magdalena Kozakowska,

Hevidar Taha, Takahiro Ochiyo, Rafal Derlacz, Elisa Vahakangas, Seppo Yia Herttuala, Alicja Jozkowics, Josef Dulak, 2010. Combined Vascular Endhotelial Growth Factor-A and Fibroblast Growth Factor 4 Gene Transfer Improves Wound Healing in Diabetic Mice. Genetic vaccines and therapy, 8:6. BioMed Central. Poland. Lari Hakkinen, Leeni Koivisto, Jryki Heino,

Hannu Larjava, 2015. Cell and Molecular Biology of Wound Healing.

Laboratory of Periodontal Biology, Faculty of Dentistry, University of

British Columbia, Vancouver. Canada.

Michael P. Seed, David A. Walsh, 2008. Angiogenesis in Inflammation : Mechanism and Clinical Correlates. Die Deutsche Bibliothek Basel, Boston. Berlin.

Phillip Bao, Arber Kodra, Marjana Tomic, Canic, Michael S. Golinko, H. paul Ehrlich, Harold Brem, 2009. The Role of Vascular Endothelial Growth Factor in Wound Healing. J. Surg Res. 153 (2) : 347-358.

Rashkit K. Devappa, Harinder P.S. Makkar, Klaus Becker, 2010. Jatropha Toxicity- A Review. Journal of Toxicology and Environmental Health, Part B. Critical Reviews, Germany.

Ricky Z. Cui, Alison J. Bruce, Roy S. Roger, 2016. Recurrent Aphthous Stomatitis. Clinic in Dermatology. Arizona.

Robert F. Diegelmann, Melissa C. Evans, 2004. Wound Healing : An Overview of Acute, Fibrotic and Delayed Healing. Department of Biochemistry, Medical College of Virginia. Virginia

Commonwealth University, Richmond. Virginia.

Sule Coskun, Emine Gulceri Gulec, Barbaros Balabanli, 2007. Effect of Epidermal Growth Factor on Lipid Peroxidation and Nitric Oxide level in Oral Mucosal Ulcer Healing. A time course study surg. Today (2007) 37; 570-574, Gazi University, Ankara. Turkey.

Xiao Wen Jiang, Yi Zhang, Hao Zhang, Kun Lu, Shou-Kang Yang, Guo Liang Sun, 2013. Double Blind, Randomized, Controlled Clinical Trial of The Effect of Diomestite and Basic Fibrobast Growth

Factor paste on Treatment of Minor Recurrent Aphthous Stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol, 2013; 116:570-575. University of South China, Chenzou, Hunan. China.

Zuzanna Slebioda, Elzbieta Szponar, Anna Kowalska, 2013. Etiopatogenesis of Reccurent Aphthous Stomatits and The Role of Immunologic Aspect : Literature Review. Poznan, Poland.

DOI: http://dx.doi.org/10.51804/jsh.v1i2.104.58-65

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